Buffalo cruised to a dominant 45-6 victory over St. Francis (PA) in Week 2, with the Bulls establishing control early and never relinquishing it. The home team scored 17 points in the first quarter and built a commanding lead throughout the contest.

Ta'Quan Roberson led Buffalo's offensive attack, connecting with receivers Victor Snow and Al-Jay Henderson while also directing the ground game that produced key scoring plays. Al-Jay Henderson rushed for 98 yards to lead the team on the ground, while Jasaiah Gathings led all receivers with 9 catches.

St. Francis (PA) managed just 6 points, all coming in the fourth quarter, as the offense struggled mightily. Jeff Hoenstine completed 4 passes for the visitors in what proved to be a lopsided affair.

Buffalo's defense made significant plays throughout, highlighted by Ta'Quan Roberson's 40-yard touchdown run in the third quarter and James McNeil Jr.'s 26-yard scoring run in the fourth. The Bulls covered the 37-point spread with ease, and the game finished over the 48-point over-under.