Louisiana Tech defeated Southern Miss 30-20 in Week 4 action. The Bulldogs controlled the game early, scoring 17 points in the first quarter and 13 in the second for a commanding 30-3 halftime lead. Southern Miss managed only a field goal in the third quarter before scoring a touchdown in the fourth.

Louisiana Tech's defense was the story, particularly in the second quarter when Kolbe Fields returned an interception 48 yards for a touchdown—the game's biggest play by EPA. The Bulldogs' offense sparked the early onslaught with Blake Baker connecting with Eli Finley on a 73-yard completion to the 1-yard line in the first quarter.

Southern Miss quarterback Braylon Braxton led the Eagles' comeback bid, finishing with 392 passing yards and connecting with Davis Dalton on a 34-yard touchdown pass in the fourth quarter. Tychaun Chapman led the receiving corps with eight catches.

Despite the lopsided final score, Southern Miss outscored Louisiana Tech 10-0 in the second half. The Bulldogs covered the 3-point spread and the game finished under the 51.5 over-under.