Missouri defeated Kansas 42-31 in a high-scoring Week 2 contest, with the Tigers pulling away late to cover the spread. Missouri quarterback Beau Pribula led the offense with 334 passing yards and added 6 rushing yards, connecting with receivers on several big plays throughout the game. Kansas kept pace early, scoring 21 points in the first quarter behind a 50-yard completion from Jalon Daniels to Levi Wentz that set up a scoring opportunity. However, Missouri controlled the middle quarters, including a 50-yard Pribula-to-Kevin Coleman Jr. completion in the second quarter that reached the Kansas 2-yard line. Kansas receiver Keaton Kubecka led all receivers with 9 catches. Missouri's defense made key plays in the fourth quarter, including a 63-yard touchdown run by Jamal Roberts and a 27-yard touchdown pass from Pribula to Brett Norfleet that sealed the victory. The game went over the 51-point over-under, with the final margin exceeding Missouri's 5.5-point spread.